Regular Turmeric & Curcumin Supplement Benefits in Over 15 (Small) Human Studies

Herbal Profile

Turmeric Starts Working in the Gut

The golden spice and it’s extracts (photo credit: NirmalSarkar)

Kidney Function and Turmeric

Turmeric Extracts, Pain and Cancer


Regular Turmeric Intake Benefits?

Odeshe’s Turmeric & Curcumin Extract, with black pepper, ginger and other vitamins & minerals
  1. Goel, A., Kunnumakkara, A. B., and Aggarwal, B. B. (2008) Curcumin as “Curecumin”: From kitchen to clinic. Biochemical Pharmacology. 75, 787–809
  2. Gupta, S. C., Sung, B., Kim, J. H., Prasad, S., Li, S., and Aggarwal, B. B. (2013) Multitargeting by turmeric, the golden spice: From kitchen to clinic. Mol. Nutr. Food Res. 57, 1510–1528
  3. Yadav, R. P., and Tarun, G. Versatility of turmeric: A review the golden spice of life
  5. Bundy, R., Walker, A. F., Middleton, R. W., and Booth, J. (2004) Turmeric Extract May Improve Irritable Bowel Syndrome Symptomology in Otherwise Healthy Adults: A Pilot Study. The Journal of Alternative and Complementary Medicine. 10, 1015–1018
  6. Khajehdehi, P., Zanjaninejad, B., Aflaki, E., Nazarinia, M., Azad, F., Malekmakan, L., and Dehghanzadeh, G.-R. (2012) Oral Supplementation of Turmeric Decreases Proteinuria, Hematuria, and Systolic Blood Pressure in Patients Suffering From Relapsing or Refractory Lupus Nephritis: A Randomized and Placebo-controlled Study. Journal of Renal Nutrition. 22, 50–57
  7. Khajehdehi, P., Pakfetrat, M., Javidnia, K., Azad, F., Malekmakan, L., Nasab, M. H., and Dehghanzadeh, G. (2011) Oral supplementation of turmeric attenuates proteinuria, transforming growth factor-β and interleukin-8 levels in patients with overt type 2 diabetic nephropathy: A randomized, double-blind and placebo-controlled study. Scandinavian Journal of Urology and Nephrology. 45, 365–370
  8. Toden, S., and Goel, A. (2017) The Holy Grail of Curcumin and its Efficacy in Various Diseases: Is Bioavailability Truly a Big Concern? J Restor Med. 6, 27–36
  9. Kuttan, R., Kuttan, G., Joseph, S., Ajith, T. A., Mohan, M., and Srimal, R. C. (2004) Antimutagenicity of herbal detoxification formula Smoke Shield against environmental mutagens. J Exp Clin Cancer Res. 23, 61–68
  10. Hewlings, S., and Kalman, D. (2017) Curcumin: A Review of Its Effects on Human Health. Foods. 6, 92
  11. Hasan Khudhair, D., Al-Gareeb, A. I., Al-kuraishy, H. M., El-Kadem, A. H., Elekhnawy, E., Negm, W. A., Saber, S., Cavalu, S., Tirla, A., Alotaibi, S. S., and Batiha, G. E.-S. (2022) Combination of Vitamin C and Curcumin Safeguards Against Methotrexate-Induced Acute Liver Injury in Mice by Synergistic Antioxidant Effects. Front Med (Lausanne). 9, 866343
  12. Cárdenas Garza, G. R., Elizondo Luévano, J. H., Bazaldúa Rodríguez, A. F., Chávez Montes, A., Pérez Hernández, R. A., Martínez Delgado, A. J., López Villarreal, S. M., Rodríguez Rodríguez, J., Sánchez Casas, R. M., Castillo Velázquez, U., and Rodríguez Luis, O. E. (2021) Benefits of Cardamom (Elettaria cardamomum (L.) Maton) and Turmeric (Curcuma longa L.) Extracts for Their Applications as Natural Anti-Inflammatory Adjuvants. Plants (Basel). 10, 1908
  13. Sukandar, E. Y., Sudjana, P., Adnyana, I. K., Setiawan, A. S., and Yuniarni, U. (2014) Recent Study of Turmeric in Combination with Garlic as Antidiabetic Agent. Procedia Chemistry. 13, 44–56
  14. Pipalia, P. R., Annigeri, R. G., and Mehta, R. (2016) Clinicobiochemical evaluation of turmeric with black pepper and nigella sativa in management of oral submucous fibrosis — a double-blind, randomized preliminary study. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 122, 705–712
  15. Ege, D. (2021) Action Mechanisms of Curcumin in Alzheimer’s Disease and Its Brain Targeted Delivery. Materials (Basel). 14, 3332
  16. Krishnaswamy, K. (2006) Turmeric: The Salt of the Orient is the Spice of Life, Allied Publishers
  17. Tapsell, L. C., Hemphill, I., Cobiac, L., Sullivan, D. R., Fenech, M., Patch, C. S., Roodenrys, S., Keogh, J. B., Clifton, P. M., Williams, P. G., Fazio, V. A., and Inge, K. E. (2006) Health benefits of herbs and spices: the past, the present, the future. Medical Journal of Australia. 10.5694/j.1326–5377.2006.tb00548.x
  18. Aggarwal, B. B., Yuan, W., Li, S., and Gupta, S. C. (2013) Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of turmeric. Mol Nutr Food Res. 57, 1529–1542
  19. Bachmeier, B. E., Mohrenz, I. V., Mirisola, V., Schleicher, E., Romeo, F., Höhneke, C., Jochum, M., Nerlich, A. G., and Pfeffer, U. (2008) Curcumin downregulates the inflammatory cytokines CXCL1 and -2 in breast cancer cells via NFκB. Carcinogenesis. 29, 779–789
  20. Kawasaki, B. T., Hurt, E. M., Mistree, T., and Farrar, W. L. (2008) Targeting Cancer Stem Cells with Phytochemicals. Molecular Interventions. 8, 174
  21. Yallapu, M. M., Maher, D. M., Sundram, V., Bell, M. C., Jaggi, M., and Chauhan, S. C. (2010) Curcumin induces chemo/radio-sensitization in ovarian cancer cells and curcumin nanoparticles inhibit ovarian cancer cell growth. J Ovarian Res. 3, 11
  22. Kuo, M.-L., Huang, T.-S., and Lin, J.-K. (1996) Curcumin, an antioxidant and anti-tumor promoter, induces apoptosis in human leukemia cells. Biochimica et Biophysica Acta (BBA) — Molecular Basis of Disease. 1317, 95–100
  23. Moragoda, L., Jaszewski, R., and Majumdar, A. P. (2001) Curcumin induced modulation of cell cycle and apoptosis in gastric and colon cancer cells. Anticancer Res. 21, 873–878
  24. Choudhuri, T., Pal, S., Agwarwal, M. L., Das, T., and Sa, G. (2002) Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction. FEBS Letters. 512, 334–340
  25. Hutchins-Wolfbrandt, A., and Mistry, A. M. (2011) Dietary Turmeric Potentially Reduces the Risk of Cancer. Asian Pac J Cancer Prev
  26. Uchio, R., Muroyama, K., Okuda-Hanafusa, C., Kawasaki, K., Yamamoto, Y., and Murosaki, S. (2019) Hot Water Extract of Curcuma longa L. Improves Serum Inflammatory Markers and General Health in Subjects with Overweight or Prehypertension/Mild Hypertension: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 11, 1822
  27. Shimouchi, A., Nose, K., Takaoka, M., Hayashi, H., and Kondo, T. (2009) Effect of Dietary Turmeric on Breath Hydrogen. Dig Dis Sci. 54, 1725–1729
  28. Wickenberg, J., Ingemansson, S. L., and Hlebowicz, J. (2010) Effects of Curcuma longa (turmeric) on postprandial plasma glucose and insulin in healthy subjects. Nutr J. 9, 43
  29. Razavi, B. M., Ghasemzadeh Rahbardar, M., and Hosseinzadeh, H. (2021) A review of therapeutic potentials of turmeric (Curcuma longa) and its active constituent, curcumin, on inflammatory disorders, pain, and their related patents. Phytotherapy Research. 35, 6489–6513
  30. Mueller, A.-L., Brockmueller, A., Kunnumakkara, A. B., and Shakibaei, M. (2022) Calebin A, a Compound of Turmeric, Down-Regulates Inflammation in Tenocytes by NF-κB/Scleraxis Signaling. Int J Mol Sci. 23, 1695
  31. Zeng, L., Yu, G., Hao, W., Yang, K., and Chen, H. (2021) The efficacy and safety of Curcuma longa extract and curcumin supplements on osteoarthritis: a systematic review and meta-analysis. Biosci Rep. 41, BSR20210817
  32. Kuttan, R., Sudheeran, P. C., and Josph, C. D. (1987) Turmeric and Curcumin as Topical Agents in Cancer Therapy. Tumori. 73, 29–31
  33. Polasa, K., Raghuram, T. C., Krishna, T. P., and Krishnaswamy, K. (1992) Effect of turmeric on urinary mutagens in smokers. Mutagenesis. 7, 107–109
  34. Hastak, K., Lubri, N., Jakhi, S. D., More, C., John, A., Ghaisas, S. D., and Bhide, S. V. (1997) Effect of turmeric oil and turmeric oleoresin on cytogenetic damage in patients suffering from oral submucous fibrosis. Cancer Letters. 116, 265–269
  35. Lal, B., Kapoor, A. K., Agrawal, P. K., Asthana, O. P., and Srimal, R. C. (2000) Role of curcumin in idiopathic inflammatory orbital pseudotumours. Phytotherapy Research. 14, 443–447
  36. Cheng, A. L., Hsu, C. H., Lin, J. K., Hsu, M. M., Ho, Y. F., Shen, T. S., Ko, J. Y., Lin, J. T., Lin, B. R., Ming-Shiang, W., Yu, H. S., Jee, S. H., Chen, G. S., Chen, T. M., Chen, C. A., Lai, M. K., Pu, Y. S., Pan, M. H., Wang, Y. J., Tsai, C. C., and Hsieh, C. Y. (2001) Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res. 21, 2895–2900
  37. Dhillon, N., Aggarwal, B. B., Newman, R. A., Wolff, R. A., Kunnumakkara, A. B., Abbruzzese, J. L., Ng, C. S., Badmaev, V., and Kurzrock, R. (2008) Phase II Trial of Curcumin in Patients with Advanced Pancreatic Cancer. Clinical Cancer Research. 14, 4491–4499
  38. Ng, T.-P., Chiam, P.-C., Lee, T., Chua, H.-C., Lim, L., and Kua, E.-H. (2006) Curry Consumption and Cognitive Function in the Elderly. American Journal of Epidemiology. 164, 898–906
  39. Esser, C., Rannug, A., and Stockinger, B. (2009) The aryl hydrocarbon receptor in immunity. Trends in Immunology. 30, 447–454
  40. Ciavarella, C., Motta, I., Valente, S., and Pasquinelli, G. (2020) Pharmacological (or Synthetic) and Nutritional Agonists of PPAR-γ as Candidates for Cytokine Storm Modulation in COVID-19 Disease. Molecules. 25, 2076



Get the Medium app

A button that says 'Download on the App Store', and if clicked it will lead you to the iOS App store
A button that says 'Get it on, Google Play', and if clicked it will lead you to the Google Play store
Odeshe Scientific

Odeshe Scientific

We love science-backed Natural Health, tools for Online Entrepreneurs and promoting community Local Shops. Explore more at